Occupational exposure to solvents and lung function decline: A population based study

SM Alif; S Dharmage; G Benke; M Dennekamp; J Burgess; JL Perret; C Lodge; S Morrison; DP Johns; G Giles; L Gurrin; PS Thomas; JL Hopper; R Wood-Baker; B Thompson; I Feather; R Vermeulen; H Kromhout; D Jarvis; J Garcia Aymerich; EH Walters; MJ Abramson; MC Matheson

Journal article

Occupational exposure to solvents and lung function decline: A population based study

SM Alif, S Dharmage, G Benke, M Dennekamp, J Burgess, JL Perret, C Lodge, S Morrison, DP Johns, G Giles, L Gurrin, PS Thomas, JL Hopper, R Wood-Baker, B Thompson, I Feather, R Vermeulen, H Kromhout, D Jarvis, J Garcia Aymerich Show all

Thorax | BMJ PUBLISHING GROUP | Published : 2019

DOI: 10.1136/thoraxjnl-2018-212267

Abstract

Rationale While cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. Objectives We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Methods Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were def..

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University of Melbourne Researchers

Sheikh Alif Author

Shyamali Dharmage Author

John Burgess Author

Jennifer Perret Author

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Grants

Awarded by University of Melbourne

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia under the NHMRC project grant scheme (299901, 1021275) and NHMRC European collaborative grant scheme (1101313) as part of ALEC (Ageing Lungs in European Cohorts) funded by the European Union's Horizon 2020 research and innovation programme under grant agreement No 633212; The University of Melbourne; Clifford Craig Medical Research Trust of Tasmania; the Victorian, Queensland and Tasmanian Asthma Foundations; The Royal Hobart Hospital; Helen MacPherson Smith Trust; and GlaxoSmithKline. The funding agencies had no direct role in the conduct of the study, the collection, management, statistical analysis and interpretation of the data, preparation or approval of the manuscript. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.